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From209US$ /night
Check-in
12Jan2026Select date
Check-out
13Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Ohio River
Great
8.7
9.3
/10
4.7
4.6
/5

Located merely 0.8 km from Belle of Louisville Riverboats|the Belle of Louisville Riverboats, the 5-star smoke-free 21C Museum Hotel Louisville is about 300 metres from the Muhammad Ali Center. Featuring a 24-hour bar, a sauna and spa therapy, the boutique hotel is right around the corner from the Louisville Slugger Museum & Bat Factory.

Location

This Louisville hotel has a central location approximately a 10-minute drive from the Big Four Bridge. Frazier International History Museum is just a few steps from the 21C Museum Hotel, and Louisville airport is 5 km away.

The accommodation is 350 m from Main / 7th bus stop.

Rooms

Some of the non-smoking rooms have an adjoining terrace and a balcony, and such facilities as a 42-inch flat-screen cable television, along with an espresso machine. The rooms have elegant furniture featuring a writing table.

Eat & Drink

Guests can also enjoy American food at Main Eatery located just near 21C Museum Hotel Louisville.

Leisure & Business

The hotel goes the extra mile to provide guests with fitness classes to help them stay fit. There is a gym on site. 17 meeting rooms with banquet facilities and a xerox are available for those travelling for business.

“The hotel distinguishes itself with its commitment to contemporary art, seamlessly integrating installations and exhibitions throughout the property. Its location near historic Whiskey Row and the Muhammad Ali Center makes it ideal for exploring downtown Louisville, and the bourbon bar adds a touch of local flavor. In my opinion, the immersive artist-designed guest rooms create a stay that is both luxurious and thought-provoking.”
Hotel logo
James DavidEditor-in-Chief at Dogfriendly-hotels
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Select your room type

The hotel provides many room choices—family rooms, doubles, and pet-friendly suites—with breakfast, free cancellation, and special offers
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Rates & availability calendar

See current prices and availability for your chosen dates!

Facilities

Hotels feature amenities designed to keep both you and your pet comfortable

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

At 21C Museum Hotel Louisville, culinary experiences await that reflect the spirit of American flavors in a modern setting. Guests can indulge in the vibrant offerings at Proof on Main, where innovative dishes and rich beverages create memorable moments, complemented by special events that celebrate regional distillers and unique spirits.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
A modern setting infused with artistic touches, creating an inviting and contemporary atmosphere that encourages conversation and connection.
Key Offerings
Signature dishes feature local ingredients, with special events such as the Fork & Bottle dinner series showcasing guest distillers and the annually celebrated Hog & Barrel dinner featuring Pappy Van Winkle.
Reservation
Reservations are recommended for dinner and special events.
Hours vary, typically open for dinner; specific timings may change according to events.

Hotel location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
A family-friendly science destination featuring interactive exhibits and an IMAX theater for immersive learning.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of baseball's iconic bat, this museum offers factory tours and unique exhibits celebrating the sport's history.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A cultural and educational center honoring the life of Muhammad Ali, featuring interactive exhibits on his legacy and humanitarian work.
KFC Yum Center
KFC Yum Center
9 minutes walking
This large arena hosts major concerts and sporting events, making it a hub for entertainment in Louisville.
Waterfront Park
Waterfront Park
17 minutes walking
A scenic park along the Ohio River, perfect for jogging, picnicking, or relaxing with outdoor yoga sessions.
Angel's Envy Distillery
Angel's Envy Distillery
19 minutes walking
Take a distillery tour and learn about the bourbon-making process, sampling unique spirits. Reservations recommended.
Louisville Bike Rentals
5 minutes walking
Rent a bike to explore the city and parks, with multiple trails available for different skill levels.
Spas and Wellness Centers
5-10 minutes drive
Local spas offer various wellness treatments, from massages to skincare, enhancing relaxation during your stay.
Proof On Main
Proof On Main
1 minute walking
A farm-to-table restaurant offering locally sourced dishes in a chic, art-filled setting, ideal for casual or fine dining.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Gourmet burgers and fresh mussels in a vibrant atmosphere, known for innovative pairings and craft beer selections.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Casual dining with a focus on Kentucky cuisine, offering a diverse menu and local craft beers. Great for family dinners.
Los Aztecas Mexican Restaurant
Los Aztecas Mexican Restaurant
3 minutes walking
Authentic Mexican dishes with a welcoming vibe, featuring vegetarian options and vibrant décor. Perfect for a casual meal.
Fourth Street Live!
10 minutes walking
An entertainment district featuring live music, dining, and nightlife, known for weekend events and a vibrant atmosphere.
Old Forester Distilling
Old Forester Distilling
15 minutes walking
Experience bourbon tastings and guided tours in a historic distillery with a lively tasting room and engaging staff.
Louisville Palace
12 minutes walking
Enjoy an exquisite historic theater with stunning decor, hosting concerts, movies, and various performances throughout the year.
Comedy Caravan
10 minutes driving
A local comedy club featuring stand-up acts. Perfect for couples or groups looking for a fun night out with laughs.
Local transport and travel tips
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
FAQs
About 21C Museum Hotel Louisville
What is the check-in and check-out policy at 21C Museum Hotel Louisville?
Check-in starts at 16:00 and check-out is by 11:00.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is available at the hotel.
What type of amenities are available in the rooms at 21C Museum Hotel Louisville?
Rooms feature free Wi-Fi, a 50-inch flat-screen TV, minibar, iPod docking station, and air conditioning.
What dining options are available at 21C Museum Hotel Louisville?
The hotel features an on-site restaurant, Proof on Main, offering unique southern cuisine.
What fitness facilities does 21C Museum Hotel Louisville offer?
There is a 24-hour fitness center, a sauna, and a range of spa services available.
Are there any notable attractions near 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), Louisville Slugger Museum & Factory (0.5 km), and the Kentucky Museum of Art & Craft (1 km).
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is 10 km from Louisville International Airport.
What services are available for business travelers at 21C Museum Hotel Louisville?
The hotel offers a business center and 17 meeting rooms for business needs.
What kind of experiences can guests expect from the art installations at 21C Museum Hotel Louisville?
The hotel includes more than 836.1 m² of exhibition space showcasing contemporary art installations.
What are some nearby dining options from 21C Museum Hotel Louisville?
Nearby restaurants include Atlantic No. 5, Main Eatery, and Morton's The Steakhouse, all within 0.5 km.

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